Tuesday 30 April 2013

Surviving in US ALL elevates possibility of contact allergies

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Posted on: Tuesday, April 30, 2013 05:06
Author: Health Yahoo UK
Subject: Living in US raises risk of allergies

 

Children born outside the United States have a lower risk of asthma, skin and food allergies, and living in the United States for a decade may raise a person's allergy risk, said a study on Monday.

The research in the Journal of the American Medical Association suggests that certain environmental exposures could trigger allergies later in life, overcoming the protective effects of microbial exposure in childhood.

The study examined records from 2007-2008 phone surveys of nearly 92,000 people in the United States, where food and skin allergies have been on the rise in recent years.

Conditions reported in the survey included asthma, eczema, hay fever, and food allergies.

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"Children born outside the United States had significantly lower prevalence of any allergic diseases (20.3 percent) than those born in the United States (34.5 percent)," said the study led by Jonathan Silverberg of St. Luke's-Roosevelt Hospital Center in New York.

"However, foreign-born Americans develop increased risk for allergic disease with prolonged residence in the United States," it said.

Children who were born outside the United States but came to live in the United States for longer than 10 years showed "significantly" higher odds of developing eczema or hay fever but not asthma or food allergies, said the research. It did not matter what age they were when they arrived.

Foreign-born children who resided in the United States for 10 years or more had nearly five times higher likelihood of eczema and more than six times higher odds of hay fever compared with foreign-born children who lived in the US for up to two years.

Silverberg said that the asthma levels seen in the study just missed the cutoff for being statistically significant.

"That is, the results may have become more significant if the study included a few thousand more children," he said in an email to AFP.

The study concluded that "duration of residence in the United States is a previously unrecognized factor in the epidemiology of atopic disease" and "foreign-born US residents might be at increased risk for later onset of allergic disease."

Previous research has shown that children who grow up in developing nations tend to have lower rates of allergies, and experts believe this is because they are exposed to more infections and microbes that build up their immune systems.

Allergies are essentially a symptom of a hypersensitive immune system, reacting to substances that should normally be considered harmless.

The JAMA study noted that the United States may not be alone in this phenomenon, since previous studies have found that immigrants in Italy, Israel, and Australia had lower allergy rates than natives.

More research is needed to find out if allergies increase in those countries among immigrants who live there for long periods, said the study.

"It's not that living in the US is bad," said Punita Ponda, a doctor in the division of pediatric allergy and immunology at Cohen Children's Medical Center of New York.

"Living in developed countries is probably thought of as a risk factor compared to living in developing countries," explained Ponda, who was not involved in the study.

"When you live in the US, you tend to lose some of that bacteria that is in the gut that protects you from allergies, and you take up the bacteria of the people around you."

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Saturday 27 April 2013

FW: Some Asian governments tighten airport controls on bird flu fears

 

 

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Posted on: Thursday, April 25, 2013 17:58
Author: Health Yahoo UK
Subject: Some Asian governments tighten airport controls on bird flu fears

 

By Sui-Lee Wee

BEIJING (Reuters) - Several governments in Asia have ordered tougher screening of air travellers from China in an effort to contain a possible spread of a new strain of bird flu that has killed 23 people in the mainland and infected one visitor from Taiwan.

The H7N9 virus has infected 109 people in China since it was first detected in March. The Geneva-based World Health Organization said it has no evidence so far of sustained transmission between people but added that this strain was more easily transmitted than an earlier, more deadly H5N1 strain that has killed hundreds around the world since 2003.

Taiwan, which reported the first H7N9 case outside of mainland China on Wednesday, said it would test air travellers for bird flu if they displayed suspicious symptoms. The island's first victim, a 53-year-old man who had returned from a visit to China's eastern city of Suzhou days before, was being treated in hospital. He said he had not had any contact with poultry.

Vietnam began screening temperatures of all visitors at its airports, officials said on Thursday, while Japan said it will allow airports and seaports to make "thermographic inspections" of travellers from China starting in May.

Thai Health Minister Pradit Sintawanarong said the country must step up precautions, adding that the health ministry will soon submit a plan to the prime minister to address the problem.

"From our assessment of the situation, there is a chance that the H7N9 virus may spread to Thailand," Sintawanarong said.

The moves came a day after a WHO expert said the H7N9 strain is "one of the most lethal" of its kind. An international team of scientists led by the WHO and the Chinese government said on Wednesday they were no closer to determining whether the virus might become transmissible between people after a five-day investigation in China.

Singapore's health ministry said its healthcare institutions "remain on heightened alert".

TAIWAN AIRLINES TANK

Shares in Taiwan's airlines fell sharply on Thursday after news of the island's first bird flu victim sparked worries that the outbreak could spread and hurt travel.

China Airlines shares shed 2.2 percent, the stock's worst daily loss since April 8. Eva Airways fell 2.4 percent to close at its lowest in about two weeks. Both underperformed the main TAIEX index, which finished flat on Thursday.

However, most Asian airlines said they had not experienced a noticeable change in bookings to China.

Raj Tanta-Nanta, a vice-president for investor relations at Thai Airways International, said the number of passengers to destinations in China had declined slightly but the national carrier had not cancelled flights to China.

Thai AirAsia also said it is not trimming flights.

"We're not cancelling flights and that may be because we fly to Yunnan, which has not faced bird flu disease," Chief Executive Tassapon Bijleveld told Reuters.

Still, the current spate of cases has sparked reminders of the impact on travel from SARS, or severe acute respiratory syndrome, which killed 774 people, mostly in China and Hong Kong in 2003.

Japan's Sharp Corp. urged its employees to "take extra precaution" when visiting China, telling them on Monday to avoid contact with birds, wash their hands and wear a mask if they develop cold or flu symptoms.

Many companies across Asia that have operations in China, including India's Tech Mahindra Ltd, said they were evaluating the situation but had not yet placed any restrictions on employees there.

POULTRY IMPORTS BANNED

Some countries tightened screening of poultry imports from China, where some bird samples had tested positive for H7N9.

Vietnam banned poultry imports from China in early April, its agriculture ministry said. The Philippines, which has banned poultry imports from China since 2004, is tightening quarantine measures on all poultry products, said Davinio Catbagan, assistant secretary for livestock at the agriculture department.

Manila has also strengthened measures to prevent the entry of smuggled poultry and other poultry products such as pigeons, Peking ducks and chicken, especially those coming from China, Catbagan said.

"The department had been notified that there are businessmen in the Philippines who illegally imports these products, which may have been contaminated by the highly pathogenic H7N9 virus and are now openly served in five-star hotels and well-known Chinese restaurants in the country," Catbagan said.

(Additional reporting by Pairat Temphairojana, Panarat Thepgumpanat and Manunphattr Dhanananphorn in BANGKOK, Kaori Kaneko and Tim Kelly in TOKYO, Clare Jim in TAIPEI, Kevin Lim in SINGAPORE, Sui-Lee Wee in BEIJING, Rosemarie Francisco in MANILA, Prak Chan Thul in PHNOM PENH, Prashant Mehra and Harichandan Arakali in NEW DELHI, Kazunori Takada in SHANGHAI, Hanoi Newsroom in HANOI, Jonathan Thatcher in JAKARTA, Writing by Sui-Lee Wee; Editing by Ken Wills)


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FW: AstraZeneca hit by generic drugs and Crestor shortfall

 

 

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Posted on: Thursday, April 25, 2013 17:12
Author: Health Yahoo UK
Subject: AstraZeneca hit by generic drugs and Crestor shortfall

 

By Ben Hirschler

LONDON (Reuters) - AstraZeneca's sales fell by a bigger-than-expected 13 percent in the first quarter as patent expiries took a heavy toll, underscoring the turnaround challenge facing Britain's second-largest drugmaker.

Much of the damage was caused by loss of exclusivity on antipsychotic medicine Seroquel and heart drug Atacand in many markets.

But the company's top-selling cholesterol fighter Crestor was also hit by generic competition in Canada, pricing pressure in Australia and worse-than-expected sales in the United States.

The poor performance suggests new Chief Executive Pascal Soriot has his work cut out to reverse the fortunes of the struggling drugmaker, despite some tentative signs of improvement in a few growth areas.

Demand for Brilinta - a new heart drug for which AstraZeneca has high hopes - picked up modestly to $51 million (33 million pounds) from $38 million in the last quarter of 2012.

Emerging markets were also a relative bright spot, with sales up 9 percent at constant currencies, largely driven by a 21 percent increase in China. Sales of a number of diabetes products, however, were lower than analysts had hoped.

"While it may be premature to judge the performance of Astra's growth platforms at this early juncture, some investors may be disappointed," said Berenberg analyst Alistair Campbell.

AstraZeneca reiterated its expectation for a mid-to-high single digit percentage fall in revenue this year, with earnings declining significantly more due to increased operating costs.

Sales in the quarter of $6.39 billion generated "core" pre-tax profit, which excludes certain items, down 25 percent at $2.23 billion and earnings down the same amount at $1.41 a share, the company said on Thursday.

Analysts had, on average, forecast sales of $6.51 billion and earnings of $1.31, according to Thomson Reuters I/B/E/S.

The beat on earnings reflected a lower-than-expected tax rate and lighter-than-anticipated expenditure, although with the full-year outlook unchanged this phasing impact is not likely to affect full-year earnings forecasts.

Shares in the group fell 2.6 percent by 0930 GMT.

In addition to the weak sales picture, there was also uncertainty over a new U.S.-led inquiry into manufacturing standards at a site in northern England.

BRILINTA INVESTMENT

Chief Financial Officer Simon Lowth said AstraZeneca's strategy was on track, in terms of investing for future growth, with a lot more effort being put behind the promotion of Brilinta in the U.S. market in particular.

"We expect to see the (Brilinta) trajectory really start to steepen and accelerate on the back of those investments towards the back-end of this year," he told reporters in a conference call.

CEO Soriot, who joined from Roche last October, set out a far-reaching plan last month to return the group to growth by axing one in 10 jobs and reorganising its drug research operations.

His plan promises no quick fixes, although he aims to double the number of drugs in late-stage development by 2016 and he says he will scour the industry for bolt-on acquisitions with which to replenish the company's medicine cabinet.

Soriot has said on several occasions that he would prefer a series of smaller "bolt-on" deals rather than a large, transformational transaction.

Whether Soriot will deliver in the long term remains to be seen - but his arrival at the group has not been cheap, leading to complaints from some shareholders about his pay package.

A group representing local pension funds in Britain is recommending that its members vote against Soriot's pay at the company's annual meeting later on Thursday.

AstraZeneca shares trade at a discount to other large pharma companies, at less than 10 times this year's expected earnings compared with close to 15 for GlaxoSmithKline and Novartis .

That reflects analyst forecasts of sliding sales and profits for several years, with its two top drugs - Nexium for stomach acid and Crestor - facing loss of U.S. patent protection in 2014 and 2016, respectively.

With cash flows set to decline, rating agencies have recently become more gloomy on AstraZeneca, with Moody's this month downgrading its credit rating for the company and Standard & Poor's cutting its outlook to negative.

(Editing by Jane Merriman and Helen Massy-Beresford)


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FW: Japan, Russia to boost business ties, restart territorial talks

 

 

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Posted on: Thursday, April 25, 2013 16:33
Author: Health Yahoo UK
Subject: Japan, Russia to boost business ties, restart territorial talks

 

By Antoni Slodkowski

TOKYO (Reuters) - Japan and Russia expect to clinch up to 20 deals, launch an investment fund and reopen talks on a territorial row that has kept them from signing a peace treaty formally ending World War Two when Japan's prime minister goes to Moscow next week.

Japan also expects Russia to present a proposal for Japan's participation in building a pipeline connecting East Siberian gas fields and a planned $38 billion Vladivostok gas hub built by Gazprom, Deputy Chief Cabinet Secretary Hiroshige Seko told Reuters on Thursday.

The summit between Shinzo Abe and President Vladimir Putin, the first between leaders of the two countries in a decade, may open the door to progress in the long-stalled territorial talks given converging strategic interests and a Japanese premier who, for the first time in a decade, appears to have the influence and staying power needed to make commitments.

Japan is the largest importer of liquefied natural gas (LNG) in the world and could provide Russia with the money and technology to develop its under-populated east. Japan, for its part, sees Russia as a strategic partner as it looks to diversify and cut the costs of LNG imports, which shot up after a 2011 disaster at its Fukushima nuclear plant.

"With the aim of diversifying energy supplies in mind, we look forward to an offer from the Russian side during this visit," Seko said. He added, however, that a major deal on the project was unlikely during Abe's visit.

Abe's trip follows two months of talks on expanding gas-supply agreements in which Japan has been pressing Gazprom to present a detailed plan of the Vladivostok project that would spell out the potential role of Japanese companies.

Abe will be accompanied by a 120-strong business delegation including 30-40 chief executives of trading houses, banking, healthcare and agriculture companies, Seko said.

"We want to sign up to 20 MOUs (memoranda of understanding) between Japanese and Russian companies and launch an investment platform," he said. Japan Bank for International Cooperation and the Russian Direct Investment Fund are looking to start a fund of up to $1 billion to encourage investment in Russia, sources told Reuters.

PERSONAL TIES

The two countries will hold a business seminar on Tuesday attended by, among others, representatives of Olympus Corp, Sumitomo Heavy Industries and Kawasaki Heavy Industries according to an agenda seen by Reuters.

"With this business mission, we want to convince Russia of the merits of having a good long-term relationship with Japan," Seko said. "Through forming strong personal ties between the leaders, we want to make Russia feel that by quickly solving the Northern Territories issue, Japan can contribute to the development of Russia and Siberia in particular."

A dispute over four sparsely populated islands in the Pacific, known as the Northern Territories in Japan and the Southern Kuriles in Russia, has prevented the countries from signing a peace treaty ending World War Two. The issue has overshadowed relations for more than 60 years.

"Until now, because of the Northern Territories, Japan wasn't able to talk to Russia about matters other than energy. That issue has always been a major bottleneck," Seko said. In February, Abe said he wants to find a "mutually acceptable solution" to the row.

The islands were seized by the Soviet Union after it declared war on Japan on August 8, 1945, just days before Japan surrendered, forcing about 17,000 Japanese to flee. They are near rich fishing grounds and close to oil and gas production regions of Russia.

Abe's visit comes a month after a Moscow trip by Chinese leader Xi Jinping. Deals between the world's biggest energy producer and its biggest customer, China, have been hard to come by. Xi's visit yielded a deal for Russian state giant Rosneft to gradually treble oil supplies to China, but the sides are short of a deal on the supply of pipeline gas to China, thwarted for years by prices.

(Editing by Linda Sieg)


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FW: AstraZeneca gets U.S. subpoena over UK drug factory

 

 

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Posted on: Thursday, April 25, 2013 16:32
Author: Health Yahoo UK
Subject: AstraZeneca gets U.S. subpoena over UK drug factory

 

LONDON (Reuters) - AstraZeneca said on Thursday it had received a subpoena from the U.S. Attorney's Office in Boston, Massachusetts, related to manufacturing standards at its Macclesfield facility in the north of England.

Britain's second biggest drugmaker said the approach was made on March 28 and the company was coordinating its response and intended to cooperate with the inquiry.

Chief Financial Officer Simon Lowth declined to go into further details about the case during a conference call with reporters following first-quarter results.

"It's a very early approach," he said.

The Macclesfield facility is AstraZeneca's second largest manufacturing site and its European centre for packing medicines. More than 800 people work at the site on the manufacturing, packing and distribution of drugs for 130 global markets.

The facility includes a unique production line for making Zoladex, used to treat hormone-sensitive cancers of the prostate and breast, according to AstraZeneca's website.

(Reporting by Ben Hirschler. Editing by Jane Merriman)


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FW: England prepares mass-vaccination as measles cases rise

 

 

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Posted on: Thursday, April 25, 2013 13:13
Author: Health Yahoo UK
Subject: England prepares mass-vaccination as measles cases rise

 


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FW: Algerian president in France for medical tests after minor stroke

 

 

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Posted on: Sunday, April 28, 2013 10:56
Author: Health Yahoo UK
Subject: Algerian president in France for medical tests after minor stroke

 

By Lamine Chikhi

ALGIERS (Reuters) - Algerian President Abdelaziz Bouteflika has been transferred to France for further medical tests after suffering a minor stroke on Saturday, Algeria's official news agency said.

The APS agency said late on Saturday that Bouteflika, 76, was in Paris at the recommendation of his doctors.

He was hospitalised after a minor stroke, according to an earlier state press agency report that quoted the prime minister as saying his condition was "not serious."

The health of Bouteflika is a central factor in the stability of the oil-exporting country of 37 million people that is emerging from a long conflict against Islamist insurgents.

APS said Bouteflika had an "ischemic transitory attack," or mini-stroke, at 12:30 p.m. (1130 GMT) on Saturday.

"A few hours ago, the president felt unwell and he has been hospitalised but his condition is not serious at all," Prime Minister Abdelmalek Sellal was quoted as saying.

Elected in 1999, Bouteflika is a member of a generation of leaders who have ruled Algeria since winning independence from France in a 1954-62 war.

They also defeated Islamist insurgents in the 1990s and saw off the challenge of Arab Spring protests two years ago, with Bouteflika's government defusing unrest through pay rises and free loans for young people.

Bouteflika has served three terms as president and is thought unlikely to seek a fourth at an election due in 2014. Leaked U.S. diplomatic cables said in 2011 that Bouteflika had been suffering from cancer, but that it was in remission.

It is unknown who might take over Africa's biggest country by land area, an OPEC oil producer that supplies a fifth of Europe's gas imports and cooperates with the West in combating Islamist militancy.

More than 70 percent of Algerians are under 30. About 21 percent of young people are unemployed, the International Monetary Fund says, and many are impatient with the gerontocracy ruling a country where jobs, wages and housing are urgent concerns.

(Reporting by Lamine Chikhi; Editing by Peter Cooney)


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FW: Gates' foundation to fund $1.8bn to eradicate polio

 

 

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Posted on: Thursday, April 25, 2013 22:38
Author: Health Yahoo UK
Subject: Gates' foundation to fund $1.8bn to eradicate polio

 

Bill Gates announced in Abu Dhabi on Thursday his foundation will contribute $1.8 billion to the Global Polio Eradication Initiative, a third of the total funds needed.

"I am pleased to announce for the foundation that we are committed to fund a third of what is needed for this campaign," the Microsoft co-founder told the Global Vaccine Summit in Abu Dhabi. "So for the fully funded campaign, that would be $1.8 billion that we are committed to."

"There has been a total of four billion dollars raised here. That gives us 73 percent of" the $5.5 billion needed, he said.

Other participants at the summit also announced their contributions -- $457 million from Britain, $250 million from Canada, and $240 million from Norway.

Abu Dhabi Crown Prince Sheikh Mohammed bin Zayed al-Nahayan announced he will donate $120 million.

Germany, which had already pledged 100 million euros, announced it will donate a similar amount again. Meanwhile, the Islamic Development Bank offered $227 million.

The number of worldwide polio infections plunged to 223 in 2012, compared to 360,000 in 1988 when the United Nations launched a campaign to eliminate the highly contagious and crippling illness.

Only three countries are still considered polio endemic -- Nigeria, Afghanistan and Pakistan.

Nigeria, where an Islamist insurgency in the country's north has taken a hit on immunisation campaigns and at least 10 people were killed in attacks on two vaccination centres in February, saw most of the cases in 2012.

At least 20 people have been killed in such attacks in Pakistan since December.

Gates, listed by Forbes as the world's second-richest person, had said the global campaign to eliminate polio was currently spending about $900 million a year.

But Medecins Sans Frontiers (MSF) has criticised the high prices of the vaccines.

"High prices for new vaccines could put developing countries in the precarious situation of not being able to afford to fully vaccinate their children in the future," warned the medical charity.

"Urgent action is needed to address the skyrocketing price to vaccinate a child, which has risen by 2,700 percent over the last decade," said Dr Manica Balasegaram, executive director of MSF's Access Campaign.

"The lack of transparency by companies on vaccine manufacturing costs and their focus on profits above ensuring sustainable prices for vaccines for low-income countries are at the root of the problem," she said.

The Bill and Melinda Gates Foundation is a major contributor to the GAVI Alliance, which helps make vaccines available to developing countries.

The two-day Global Vaccine Summit was aimed at highlighting the need for continued support for immunisations, as well as discuss a six-year plan to eliminate polio.


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FW: Scientists confirm new H7N9 bird flu has come from chickens

 

 

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Posted on: Thursday, April 25, 2013 20:48
Author: Health Yahoo UK
Subject: Scientists confirm new H7N9 bird flu has come from chickens

 

By Kate Kelland

LONDON (Reuters) - Chinese scientists have confirmed for the first time that a new strain of bird flu that has killed 23 people in China has been transmitted to humans from chickens.

In a study published online in the Lancet medical journal, the scientists echoed previous statements from the World Health Organization (WHO) and Chinese officials that there is as yet no evidence of human-to-human transmission of this virus.

The H7N9 strain has infected 109 people in China since it was first detected in March. The WHO warned on Wednesday that this strain is "one of the most lethal" flu viruses and is transmitted more easily than the H5N1 strain of bird flu, which has killed hundreds around the world since 2003.

Kwok-Yung Yuen of the University of Hong Kong, who led the study, said its findings that chickens in poultry markets were a source of human infections meant that controlling the disease in these places and in these birds should be a priority.

"Aggressive intervention to block further animal-to-person transmission in live poultry markets, as has previously been done in Hong Kong, should be considered," he told the Lancet.

He added that temporary closure of live bird markets and comprehensive programmes of surveillance, culling, biosecurity and segregation of different poultry species may also be needed "to halt evolution of the virus into a pandemic agent".

"The evidence ... suggests it is a pure poultry-to-human transmission and that controlling (infections in people) will therefore depend on controlling the epidemic in poultry," he said.

Yuen's findings do not mean all cases of human H7N9 infection come from chickens, or from poultry, but they do confirm chickens as one source.

The WHO has said 40 percent of people infected with H7N9 appear to have had no contact with poultry.

Other so called "reservoirs" of the flu virus may be circulating in other types of birds or mammals, and investigators in China are working hard to try find out.

CASE STUDIES

Yuen's team conducted detailed cases studies on four H7N9 flu patients from Zhejiang, an eastern coastal province south of the commercial hub Shanghai.

All four patients had been exposed to poultry, either through their work or through visiting poultry markets.

To find out whether there was transmission of the virus from poultry to humans, the researchers took swabs from 20 chickens, four quails, five pigeons and 57 ducks, all from six markets likely to have been visited by the patients.

Two of the five pigeons and four of the 20 chickens tested positive for H7N9, but none of the ducks or quails.

After analysing the genetic makeup of H7N9 virus in a sample isolated from one patient and comparing it to a sample from one of the chickens, the researchers said similarities suggest the virus is being transmitted directly to humans from poultry.

The team also checked more than 300 people who had had close contact with the four patients and found that none showed any symptoms of H7N9 infection within 14 days from the beginning of surveillance. This suggests the virus is not currently able to transmit between people, they said.

But they noted that previous genetic analysis shows H7N9 has already acquired some gene mutations that adapt it specifically to being more able to infect mammals - raising the risk that it could one day cause a human pandemic.

"Further adaptation of the virus could lead to infections with less severe symptoms and more efficient person-to-person transmission," the scientists wrote.

(Editing by Kevin Liffey)


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FW: New $5.5 billion plan aims to rid world of polio by 2018

 

 

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Posted on: Thursday, April 25, 2013 18:49
Author: Health Yahoo UK
Subject: New $5.5 billion plan aims to rid world of polio by 2018

 

By Kate Kelland, Health and Science Correspondent

LONDON (Reuters) - Health groups said on Thursday they could rid the world of polio by 2018 with a $5.5 billion (3.5 billion pounds) vaccination and monitoring plan to stop the disease taking hold once more now there are only a handful of cases worldwide.

Experts say the plan offers the best chance yet to eradicate a disease that until the 1950s crippled many thousands of people every year but has been brought almost to extinction though effective vaccine campaigns.

In 1988, more than 350,000 children were paralysed by polio and the disease was endemic in more than 125 countries. Last year, worldwide polio cases plunged from 650 in 2011 to 223, the largest drop in a decade.

So far in 2013, 19 cases have been reported and polio remains endemic in just three countries - Pakistan, Afghanistan and Nigeria - after India celebrated its second polio-free year.

"Today we have the fewest cases in the fewest places ever, making it critical to use the best opportunity the world has ever had to put an end to this terrible, preventable disease," Anne Schuchat, a global health specialist at the U.S. Centers for Disease Control and Prevention (CDC), said in a statement.

The virus attacks the nervous system and can cause irreversible paralysis within hours of infection. It often spreads in areas with poor sanitation and children under five are the most vulnerable, but it can be halted, as it was in many developed countries, with comprehensive vaccination programmes.

The polio plan's $5.5 billion budget includes the costs of reaching and vaccinating more than 250 million children multiple times every year, monitoring and surveillance in more than 70 countries, and securing the infrastructure that health campaigners hope will go on to help other health programs.

CASH BACKING

In a statement issued by the World Health Organisation, world leaders and individual philanthropists backed the plan by the Global Polio Eradication Initiative (GPEI) by pledging almost three-quarters of the funds up front.

"After millennia battling polio, this plan puts us within sight of the endgame," said the WHO's director-general Margaret Chan. "We have new knowledge about the polio viruses, new technologies and new tactics to reach the most vulnerable communities."

The GPEI, launched in 1988, is a grouping of governments, the WHO, Rotary International, the CDC and the United Nations children's fund UNICEF, supported by philanthropic groups such as the Gates Foundation.

Speaking at a summit on vaccines in Abu Dhabi, Bill Gates said his foundation would stump up $1.8 billion - a third of the total cost of the GPEI's six-year budget.

Another $335 million was promised by a seven-strong group of other philanthropists, including the Tahir Foundation, Bloomberg Philanthropies and the Carlos Slim Foundation.

Multiple government donors - among them Britain, Germany, Norway, Pakistan and Nigeria - also made pledges, bringing the total promised so far for the plan to just over $4 billion.

Public health experts say if the polio eradication campaign succeeds, the world would not only declare its second eradicated disease - smallpox was wiped out in 1979 - it would also be billions of dollars richer.

A 2010 analysis found that if polio transmission were to be stopped by 2015 the net benefit from reduced treatment costs and productivity gains would be $40 billion to $50 billion by 2035.

(Editing by Alison Williams)


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Fireplace eliminates many within Ruskies psychological medical center

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Posted on: Friday, April 26, 2013 22:15
Author: Health Yahoo UK
Subject: Fire kills dozens in Russian psychiatric hospital

 

Thirty-eight people were killed, most of them in their beds, in a fire that raged through a psychiatric hospital near Moscow on Friday, raising questions about the care of mentally ill patients in Russia.

The fire, which broke out at around 2 a.m. (2300 BST on Thursday), swept through a single-storey building at the hospital, a collection of wood and brick huts with bars on some windows that was home to people sent there on grounds of mental illness by Russian courts.

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By mid morning, a few blackened walls were left standing. The roof had caved in on top of the twisted metal frames of what were once beds. Bodies lay on nearby grass, covered with blankets.

Only three people escaped from the fire in the village of Ramensky, 120 km (70 miles) north of Moscow, prompting speculation the patients were heavily sedated or strapped down.

Irina Gumennaya, aide to the head of the chief investigative department of the Moscow region, dismissed suggestions they had been restrained as "rubbish" but promised blood tests to check whether there were high levels of sedatives.

"The wards ... did not have doors, the patients could have escaped from the building by themselves," she said, adding that she believed the most likely cause of the blaze was patients smoking, or perhaps a short circuit.

Health Minister Veronika Skvortsova said none of the patients were strapped down or subjected to "any such measures that would not have allowed them to react quickly," the state-run RIA news agency reported.

President Vladimir Putin called for an investigation of the "tragedy", the latest in a long line of disasters at state institutions that are often ill-funded. Russia's safety record is dismal, accounting for a high death toll on roads, railways and in the air as well as at the workplace.

Psychiatrists said the fire was not the first and would not be the last of its kind.

"(This happened) because of dilapidated buildings in psychiatric hospitals - a third of the buildings since 2000 have been declared unfit, according to health standards," Yuri Savenko, president of the independent psychiatric association of Russia, told Reuters.

Furthermore, junior and middle-ranking staff had miserable salaries and "because of that the staff were asleep", he said.

Legal standards governing Russian psychiatric patients "are on the whole satisfactory and on par with European standards, but compliance with them is very weak," lawyer Dmitry Agranovsky said.

RUSSIA - "THE MADHOUSE"

Putin's critics blamed the state for neglecting its most vulnerable people.

"Terrible news ... Those patients who burned were there because they were forced to have treatment," said Dmitry Olshansky, former editor of Russian Life, an online journal.

"I read all this and I wonder - what does this remind us of? And then I remember - this is our motherland, the madhouse. Flood, fire, bars on windows ... and we cannot deal with it," he said on his Facebook site.

Officials said the blaze consumed the building quickly and fire-fighters had no chance to save any more people - an account that locals disputed, saying fire engines took more than an hour to reach the scene.

"Don't trust anyone who says they (firemen) arrived quickly ... My wife woke me up, we went out on the street with our daughter. Flames were rising high," said a man, who was drinking an early-morning beer at a friend's garage nearby.

Asked why the building caught fire, Alexander Yefimovich, an elderly man said: "Why? It's just the usual nonsense."

More than 12,000 people were killed in fires in 2011 and more than 7,700 in the first nine months of 2012 in Russia, where the per capita death rate from fires is much higher than in Western nations including the United States.

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Friday 19 April 2013

OFT accuses GSK more than "pay-for-delay" medicine offers

The Office of Fair Trading (OFT) accused GlaxoSmithKline of market abuse for striking deals with three generic drugmakers that paid them to delay launching cheap copies of its antidepressant Seroxat.

GSK, Britain's biggest drugmaker, said it believed it had acted lawfully. If it is found to have broken the law, it could be fined up to 10 percent of its worldwide turnover, which amounted to 26.4 billion pounds in 2012.

The move by the OFT is the latest example of regulators trying to curb "pay-for-delay" deals, following a series of investigations against drug companies by U.S. and European antitrust officials.

The OFT alleged on Friday that GSK concluded anti-competitive agreements with Alpharma, Generics (UK) and Norton Healthcare over the supply of paroxetine - a top-selling medicine sold by GSK under the brand name Seroxat.

The case relates to deals struck a decade ago. The patents protecting paroxetine - known as Paxil in the United States - have now expired and the supply agreements under investigation were terminated in 2004.

The OFT said the agreements included substantial payments from GSK to the generic companies in return for their commitment to delay launching their products. This amounted to an abuse of GSK's dominant market position, it said.

GSK disputes the allegations, which relate to deals that were effective between 2001 and 2004.

"GSK supports fair competition and we very strongly believe that we acted within the law," the company said, adding that the deals resulted in generic versions of paroxetine entering the market before GSK's patents expired.

GSK also said the paroxetine case had been reviewed by the European Commission in 2005-2006 and the EU body, which acts as antitrust regulator, formally concluded its inquiry last year with no further action.

COST SAVINGS

The OFT said it had a duty to investigate the case given the importance of generic medicines in keeping a lid on costs for the country's National Health Service (NHS).

"The introduction of generic medicines can lead to strong competition on price, which can drive savings for the NHS, to the benefit of patients and, ultimately, taxpayers," said Ann Pope, senior director of services, infrastructure and public markets at the OFT.

The companies will have an opportunity to respond to the allegations before the OFT decides if competition law has been infringed.

Mike van Dulken, head of research at Accendo Markets, said the case had taken the shine of GSK shares, following a strong performance earlier in the week, even though Seroxat/Paxil sales were only 1.4 percent of group sales in 2012.

The stock was down 0.5 percent by 10.18 a.m. BT, underperforming a 0.4 percent rise in the FTSE 100 index <.ftse>.</.ftse>

The issue of brand-name pharmaceutical companies paying makers of generic drugs to drop patent challenges was also at the centre of a European review of the sector in 2008-2009, which did not result in any action against GSK.

The topic has been thrown into the spotlight in recent years because of the growing role of generics in supplying cut-price copies of ageing blockbuster medicines in Western markets at a fraction of the cost of the originals.

In the United States, the Federal Trade Commission has also fought against pay-for-delay deals in court for more than a decade. The issue is now in front of the U.S. Supreme Court, which is expected to issue a decision by the end of June.

 

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Sunday 14 April 2013

Indian native woman along with inflamed mind requirements 'miracle': moms and dads

The eager Indian native dad in whose young lad is suffering from an ailment which triggered the girl visit enlarge as much as a massive dimension stated Weekend he could be praying for any "miracle" in order to save the girl living.

Eighteen-month-old Roona Begum was diagnosed with hydrocephalus, in which cerebrospinal fluid builds up in the brain, just weeks after her birth in a government-run hospital in remote Tripura state in northeast India.

The potentially fatal illness has caused Roona's head to swell to a circumference of 91-centimetres (36-inches), putting pressure on her brain.

Her father, Abdul Rahman, 18, who lives in a mud hut with his family in the village of Jirania Khola, told AFP he prays for "a miracle" that will save his only child.

"Day by day, I saw her head growing too big after she was born," said the illiterate labourer who works in a brick-making factory.

Doctors told him to go to a specialist hospital in a big city such as Kolkata in eastern India to get medical help but Rahman, who earns 150 rupees ($2.75) a day working in the brick plant, said he does not have the money to take her.

"It's very difficult to watch her in pain. I pray several times a day for a miracle -- for something to make my child better," he said.

The US government's National Institute of Neurological Disorders and Stroke estimates about one in every 500 children suffers from hydrocephalus.

The most common treatment involves the surgical insertion of a shunt system to drain cerebrospinal fluid away from the brain and towards another part of the body where it can be easily absorbed into the bloodstream.

Cases like Roona's, where the head has doubled in size in a relatively short span of time, are extremely rare, according to leading Indian neurosurgeon Sandeep Vaishya.

"It's difficult to assess the situation without seeing the patient, but a surgery, even at this late stage, would give her brain the best chance it has to grow and develop normally," Vaishya told AFP.

Vaishya, who is the head of neurosurgery at the privately run Fortis flagship hospital in Gurgaon, a satellite city of the national capital Delhi, said that surgeries to treat hydrocephalus cases are "not particularly risky".

Although the cost differs from case to case, he estimated that a complex surgery like this one would cost about 125,000 rupees ($2,300) and require a three-day hospital stay.

Roona now is confined to her bed and unable to move her head but she is a playful child, quick to smile and giggle and is able to move her limbs, according to her father.

She has outlived an initial prognosis by doctors that she would survive only two months.

But her mother, Fatema Khatun, 25, says the little girl's health is getting worse and that she urgently needs help.

"She is deteriorating. She eats less and less, vomits often and I can see that she is getting thinner," Khatun told AFP.

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Friday 12 April 2013

US public health experts said developing a vaccine for the H7N9 strain of bird flu could take "many months"

Chinese authorities have confirmed 43 human cases of H7N9 avian influenza since announcing nearly two weeks ago that they had found the strain in humans for the first time.

Writing in the New England Journal of Medicine, Timothy Uyeki and Nancy Cox of the US Centers for Disease Control and Prevention (CDC) said worldwide efforts to develop a vaccine had started, but it would take time.

"Even if new vaccine manufacturing technologies... are utilised, the process from vaccine development to availability will probably take many months," said the article posted on the journal's website on Thursday.

China said this week it expects to have a vaccine ready in seven months.

Chinese health officials say they do not know exactly how the virus is spreading, but it is believed to be crossing to humans from birds.

The journal article said the outbreak was a "seminal event" that raised global concerns and it urged China to enhance surveillance.

"It might herald sporadic human infections from an animal source... or it might signal the start of an influenza pandemic," the article said.

Experts fear the prospect of such viruses mutating into a form easily transmissible between humans, which has the potential to trigger a pandemic.

The World Health Organization (WHO) said on Monday that there was no evidence of human-to-human transmission.

Shanghai, which has 20 confirmed cases, was the first to halt trading in live poultry and cull birds last week, followed by other cities in eastern China -- the site of the outbreak.

In Nanjing, a woman cut an official with a broken bottle as she tried to protect her chickens after the city barred residents from raising poultry at home and ordered them to cull birds, China News Service said Friday.

"I want to get bird flu, so I can infect you," the emotional woman told urban management officials seeking to kill her birds.

The United Nations' Food and Agriculture Organization (FA0) on Thursday expressed worry over the possible spread of H7N9 to China's neighbours through infected poultry.

"There is a possibility that if inadvertently or advertently somebody moves infected poultry across the border from one country to another you can have a spread of the virus," said Subhash Morzaria, Asia regional manager for the FAO's emergency centre for animal diseases.

Japan on Friday gave itself new powers aimed at curbing outbreaks of infectious diseases in people, as it nervously watches the spread of H7N9 bird flu in neighbouring China.

Under a new law, the government can strengthen quarantines at airports, vaccinate doctors and government officials, shut schools and cancel events with large numbers of people.

China has earned international approval for its transparency for H7N9, after being accused of covering up Severe Acute Respiratory Syndrome (SARS) in 2003.

"Chinese scientists are to be congratulated for the apparent speed with which the H7N9 virus was identified," said the New England Journal of Medicine article, adding they had quickly made public the genome sequences.

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